Describe two differences between tramadol and tapentadol.

Describe two differences between tramadol and tapentadol.

• A. Tramadol has weak mu agonist activity with serotonergic and norepinephrine reuptake effects; Tapentadol provides mu agonism plus norepinephrine reuptake inhibition with fewer serotonergic interactions
• B. Tramadol is a pure mu antagonist
• C. Tapentadol has stronger serotonergic effects than tramadol
• D. They are identical in mechanism

Answer: (A)