Explain the concept of incomplete cross-tolerance and its relevance to opioid rotation.

Explain the concept of incomplete cross-tolerance and its relevance to opioid rotation.

• A. Tolerance to one opioid does not fully transfer to another; when rotating opioids, start at a reduced equianalgesic dose (commonly 25–50% decrease) and titrate to effect.
• B. Tolerance to one opioid fully transfers; rotate at the same equianalgesic dose.
• C. No consideration is needed when rotating opioids.
• D. You should avoid rotation due to increased risk of overdose.

Answer: (A)