Where are myofibroblasts found?

Where are myofibroblasts found?

• A. Sites of Inflammation
• B. Bone Tissue
• C. Nervous Tissue
• D. Muscle Tissue

Answer: (A)

In wound healing, myofibroblasts arise from fibroblasts under inflammatory signals (like TGF-β) and become contractile cells that help close the wound and remodel the extracellular matrix. They are most prominently found in sites of inflammation, especially within granulation tissue at healing edges, where their spindle shape and expression of smooth muscle–like actin drive wound contraction. They’re not normal residents of bone, nervous, or muscle tissue, which is why those tissues aren’t where myofibroblasts are typically located. This is why the correct setting is sites of inflammation.

In wound healing, myofibroblasts arise from fibroblasts under inflammatory signals (like TGF-β) and become contractile cells that help close the wound and remodel the extracellular matrix. They are most prominently found in sites of inflammation, especially within granulation tissue at healing edges, where their spindle shape and expression of smooth muscle–like actin drive wound contraction. They’re not normal residents of bone, nervous, or muscle tissue, which is why those tissues aren’t where myofibroblasts are typically located. This is why the correct setting is sites of inflammation.